Neuromultivit instructions for use side effects. Tablets Neuromultivit and its cheap analogues: instructions for use

Neuromultivit is a complex multivitamin preparation consisting of 3 B vitamins (B1, B6, B12). It is used to treat various kinds of neurological diseases, since it effectively stimulates metabolic processes in the central nervous system and activates the restoration of nerve tissues.

The drug is prescribed, both independently and in combination with other drugs. Its effectiveness has been proven in the treatment of neuritis and neuralgia, polyneuropathy of various origins, inflammation of the trigeminal, facial and sciatic nerves. Neuromultivit has also established itself as an excellent medicine for attacks of pain in the lower back, shoulder joints, and osteochondrosis.

Due to the positive effect on the central nervous system, the drug is prescribed to emotionally unstable people with frequent stress. In addition, Neuromultivit acts as an analgesic and supports the body during the cold season.

The remedy is prescribed both for the treatment of many diseases, and for prevention. It is included in combination with other drugs for diabetes, hair loss, alcoholism. Also, the drug is additionally introduced into the antibiotic treatment regimen for diseases of the gastrointestinal tract.

Athletes also appreciated neuromultivit, as it accelerates the recovery of strength and supports the body during overloads.

Neuromultivit - instructions for use and analogues

The drug is released without a prescription. Analogues of Neuromultivit - Pentovit, Brewer's yeast, Beviplex, Milgamma Compositum, Neurobeks.

The price of Neuromultivit

The price of Neuromultivit in Moscow is 235 rubles. 20 pcs. 638 rub. 60 pcs.

The price of Neuromultivit in Ukraine is 162 UAH. 20 pcs.

Real reviews about Neuromultivit

• Hello friends! I had to deal with this drug, I want to share my experience with you. As you know, this is a complex of vitamins, each of them acts on different problem areas. I have a problem with my back, I constantly pinch a nerve, and there are often outbursts of irritability. I never thought that it could be from a lack of vitamin B. I am a frequent visitor to hospitals, but recently a new neuropathologist has appeared in our clinic. After looking at my medical history, he prescribed Neuromultivit for me. I didn’t pay much attention anymore, as I took many different drugs all the time. I drank 2 tablets a day for 2 weeks, then I passed the tests and the doctor said that this was enough. But even without analysis, I felt that something was happening to me. I was shocked at the result. Back pain has been significantly reduced! Not a magical cure, but the movements are not so constrained, and if I suddenly turn around, it does not hurt like before. I am very satisfied with the drug, I did not notice any side effects.
• Neuromultivit was prescribed by a doctor friend after a thorough examination. I took one tablet for a month, then again an examination, and after a break for another month at the same dosage. The result is obvious, I became calmer, and most importantly, I stopped suffering with my leg, it either went numb, then it hurt, it pulled right from the lower back, I could not find a place for myself. Still, you can’t turn a blind eye to health problems, everything is allowed, you just need to see a doctor. Thank you very much to my friend for such a clear diagnosis and prescription of treatment with this drug. I did not even think that a complex of vitamins is capable of such a result. But she said that these are very serious vitamins and you can’t take them on your own without an appointment. Take care of yourself!
• I love sports, I go in for weightlifting, as you understand, I give serious loads. Once I had a pinched nerve in my back. I went to the doctor, he prescribed me Neuromultivit. I took a month, 1 tablet a day, my back was released, but my whole body was sprinkled with small abscesses. I turned to another specialist, it turned out that this was a large dose for me. After a while after the drug was discontinued, everything improved and nothing like this arose, my health also improved, no pinching. Be very careful with the choice of a specialist. All good health!

Instruction

The multivitamin preparation "Neuromultivit" is prescribed as part of the complex therapy of the following diseases of the nervous system: neuralgia, neuritis, plexitis, intercostal neuralgia, sciatica, lumbago, trigeminal neuralgia, diabetic and alcoholic polyneuropathy, degenerative pathologies of the spine with radicular syndrome. The drug is released in coated. One tablet contains vitamin B1 (100 mg), vitamin B6 (200 mg) and vitamin B12 (0.20 mg). The tool stimulates the metabolism in the nervous system, improves the recovery processes in the nervous tissue, and also has some analgesic effect.

Features of the mechanism of action of the drug are due to its components. Vitamin B1 in the body is converted into cocarboxylase, which takes part in many metabolic processes, and also participates in the transmission of nerve impulses in nerve endings (synapses). Vitamin B6 is required for the normal functioning of the nervous system, takes part in the synthesis of many neurotransmitters (dopamine, norepinephrine, histamine, etc.). Vitamin B12 is involved in hematopoiesis, metabolism, it is necessary for the body for the processes of cell division and growth.

Take Neuromultivit after meals with water, 1 tab. 1-3 times a day. The duration of therapy is determined by the doctor, usually it is 2-4 weeks. The drug has a therapeutic effect within 1-2 weeks after the start of administration. It is not recommended to take Neromultivit for longer than 4 weeks. The drug is contraindicated in case of hypersensitivity to the components of the drug, during periods of pregnancy and lactation. The drug causes side effects in rare cases. These include: nausea, itching, rash, tachycardia.

"Neuromultivit" reduces the effectiveness of antiparkinsonian drugs ("Levodopa"). Ethanol intake dramatically reduces the absorption of vitamin B1. During the use of the drug, it is not recommended to take other drugs containing vitamins of group B. Analogues of Neuromultivit are: Angiovit, Sana-Sol, Pikovit, Vitacitrol, Viabex, Revit, Milgamma , "Neurogamma", "Combilipen", "Unigamma", "Kaltsevita", "Neurotrat Forte". It is necessary to replace the drug with an analogue only after consulting a doctor. "Neuromultivit" is stored in a dark, dry place out of the reach of children. The storage temperature should not exceed 25 °C. The shelf life of the product is 3 years.

Neuromultivit is a complex vitamin preparation. It is necessary to use the drug only on the advice of a doctor.

Composition and form of release

Release form

Produced in the form of round tablets, characterized by biconvexity and film coating. Surface color is white. The color on the cut ranges from white to light pink, blotches are possible. Neuromultivit pack contains 1 blister containing 20 tablets. Sold by prescription.

The composition of the tablets

• Active ingredients: 100 mg thiamine hydrochloride, 200 mg pyridoxine hydrochloride, 0.2 mg cyanocobalamin per tablet.
• Excipients: microcrystalline cellulose, magnesium stearate, povidone.
• Shell: macrogol 6000, titanium dioxide, talc, hypromellose, methyl methacrylate and ethyl acrylate copolymer 1:2.

Storage: According to the instructions, Neuromultivit should be stored in conditions that meet the following requirements: lack of humidity, light, inaccessibility to children, temperature not higher than 25 degrees.

pharmachologic effect

Neuromultivit contains the following vitamins:

• Thiamine, or vitamin B 1. This vitamin after metabolic processes in the body is able to transform into cocarboxylase. And this is an integral part of special enzymes that affect the rate of biochemical processes in the direction of its increase. In addition, vitamin B 1 is directly involved in the metabolism of fats, proteins and carbohydrates, and also contributes to the conduction of nerve impulses between the cells of the nervous system. In the preparation Neuromultivit, this vitamin is in the amount of 100 mg.
• Pyradoxine, or vitamin B 6. With its deficiency in the body, violations of the peripheral and central nervous systems are possible. This element is an integral component of enzymes that take part in the metabolism of amino acids, as well as in the process of formation of neurotransmitters - substances that allow nerve cells to exchange information. In the preparation Neuromultivit this vitamin is in the amount of 200 mg.
• Cyanocobalamin, or vitamin B 12. This vitamin is involved in the process of hematopoiesis and the formation of red blood cells. In addition, it is directly involved in some biochemical processes that are necessary for the normal functioning of the body. For example, the exchange of amino acids, carbohydrates, fats, the formation of nucleic acids and proteins. Also, it is this vitamin, which is part of the product, that is able to activate the blood coagulation function and the functioning of the liver as a whole. Cyanocobalamin affects the processes of the nervous system, and forms of the vitamin are involved in cell division and growth. Neuromultivit contains this vitamin in an amount of 200 mcg.

If we take the effect of the drug, then it affects the work of metabolic processes that occur in nerve cells, as well as the restoration of nervous tissue. That is why this remedy is very effective for the treatment of neurological diseases. In combination with other medicines, it is used to treat diseases of the nervous system.

Indications for the use of Neuromultivit

• polyneropathy (the etiology of the disease does not matter) is damage to the nervous peripheral nervous system as a result of exposure to toxic substances or metabolic disorders, for example, with diabetes mellitus or prolonged alcoholism;
• neuritis;
• neuralgia;
• paresis of the facial nerve (violations of facial expressions);
• with cervical syndrome - neurological disorders in the neck, the characteristic symptoms of which are pain and mobility disorders;
• humeroscapular syndrome;
• radicular syndrome, which may be the result of a degenerative change in the spine;
• sciatica, or inflammation of the sciatic nerve;
• lumbago;
• plexitis;
• postoperative period;
• Neuromultivit is prescribed during the recovery period after an infectious disease;
• psycho-emotional overload;
• use in hypovitaminosis.

What diseases does Neuromultivit help with:

It is used in the treatment of the following diseases:

• diabetes;
• alcoholism;
• hair loss.

Contraindications

• hypersensitivity to the components of the drug;
• age up to 12 years;
• propensity to allergies;
• stomach ulcer during an exacerbation;
• Neuromultivit is contraindicated in Wakez disease;
• erythrocytosis;
• embolism.

Side effects

• from the nervous system: peripheral sensory neuropathy (subject to long-term use of the drug in an amount of more than 50 mg in the equivalent of vitamin B 6), nervous agitation, headaches and clouding of consciousness, general malaise;
• on the part of the gastrointestinal tract Neuromultivit can cause: nausea, vomiting, diarrhea, pain in the abdomen, increased acidity of gastric juice;
• on the part of immunity: anaphylactic shock, skin reactions, for example, itching or urticaria;
• sensitivity disorders;
• excessive sweating;
• tachycardia.

In most cases, Neuromultivit is well tolerated, without any side effects. However, with an increase in the allowable dose of use for a long time (about 6-12 months), side effects are possible.

Instructions for use

The main method of administration is oral. In case of damage to the shell of the tablets, it can lead to violations of the pharmacokinetic profile of the drug. That is why during the use of the drug it is forbidden to crush the tablet in any way: turning into powder or chewing. To achieve the maximum effect from taking the medicine, it is necessary to strictly follow the rules for taking it: do it only after eating, and almost immediately. You can take the tablets with clean water, juice or warm tea. Hot tea, as well as coffee, will not work for this purpose.

Method and dosage

The treatment regimen for Neuromultivit is exclusively made by the attending physician, who makes appointments depending on many factors:

• the severity of the symptoms of the diagnosed disease;
• concomitant therapy;
• the patient's general condition.

The instructions indicate, as a rule, the treatment regimen is as follows: 1 tablet from 1 to 3 times a day. When taking an increased dosage (the decision to prescribe higher doses is taken by the doctor), the course of treatment should not exceed 4 weeks. If necessary, the course of treatment should be repeated, however, not earlier than after a two-week break.

Neuromultivit for children

Due to the peculiarity of the action of the drug, namely its ability to be included in cellular metabolism, normalizing its functions, and also due to the function of restoring the functioning of the nervous system, Neuromultivit can also be used by children, even newborns.

For the child's psyche, it is extremely necessary that a sufficient amount of vitamin B 6 enter the body, since it contributes to the development of neurodermatitis. It is also a source of energy. Vitamin B 12 improves the supply of oxygen to the tissues and organs of the child. That is why it is often used to treat childhood neurological conditions. In addition, the drug is well tolerated, and side effects are extremely rare.

According to the instructions, there are some restrictions on the use of Neuromultivit by children:

• should not be given at night, as there is a risk of insomnia;
• appointments are all carried out by the doctor, since the drug, although it contains only vitamins, but in large quantities, which threatens to overdose if they are taken incorrectly.

During pregnancy and lactation

Reliable clinical data that indicate the safety of the drug for the fetus during pregnancy, so it is better to refuse Neuromultivit during this period.

Overdose

• with prolonged use of high doses of vitamin B 1 (more than 10 g per day), a curare-like effect may occur, as a result of which the conduction of nerve impulses is suppressed;
• vitamin B 6 is not highly toxic, however, if it is taken excessively, neuropathy may develop in combination with atoxia, in some cases seborrheic dermatitis, hypochromic anemia (when the daily norm is exceeded by 2 g), neurotoxic effects (with a daily intake of more than 1 g of vitamin);
• vitamin B 12, when administered parenterally, allergic reactions, acne, disorders in the work of liver enzymes, pain in the heart area, as well as hypercoagulation are possible.

Treatment: There is no special agent that helps to eliminate the side effects of taking Neuromultivit. If symptoms of an overdose of the drug appear, the use of tablets should be stopped and, if necessary, symptomatic treatment should be carried out.

special instructions

If Neuromultivit is taken by patients diagnosed with funicular myelosis or pernicious anemia, then the clinical picture of the disease, as well as the results of laboratory tests, may lose their specificity. Patients suffering from severe kidney or liver dysfunction, as well as gastric and duodenal ulcers should be under the constant supervision of the attending physician.

Interaction with other drugs

Neuromultivit is able to influence the actions of other drugs while using:

• levodopa: reduces antiparkinsonian activity;
• ethyl alcohol: intestinal absorption of thiamine decreases;
• phenobarbital, carbamazepine, phenytoin: development of thiamine deficiency;
• colchicine, biguanides: decreased absorption of cyanocobolamin;
• isoniazid, oral contraceptives, penicillin: the effectiveness of vitamin B 6 is reduced.

Domestic and foreign analogues

1. Neurobiron - the main application is the therapy of neuritis, neuralgia. In addition, it shows high efficiency in the treatment of lumbar syndrome and facial nerve.
2. Aerovit - in its composition has all the B vitamins, vitamins E, C, A and PP. Like Neuromultivit, this analogue serves to restore the metabolism in the body, improve mental and physical activity, and also tones the body.
3. Vetoron is a drug of complex action, which in its composition contains vitamins, characterized by pronounced antioxidant activity. The active substances of the drug are part of the enzymes that are directly involved in metabolic processes.
4. Revit is an analogue of Neuromultivit, a complex drug whose pharmacological action is due to the vitamins present: retinol palmitate (normalization of protein and carbohydrate metabolism), thiamine hydrochloride (normalization of nervous system functions), ascorbic acid (participates in tissue regeneration and blood coagulation).

Price in pharmacies

The price of Neuromultivit in different pharmacies can vary significantly. This is due to the use of cheaper components and the pricing policy of the pharmacy chain.

Read the official information about the Neuromultivit preparation, the instructions for use of which include general information and a treatment regimen. The text is provided for informational purposes only and is not a substitute for medical advice.

Release form, composition and packaging

Film-coated tablets white or almost white, round, biconvex; on a transverse section - from white to light pink with patches from light pink to dark pink.

Excipients: microcrystalline cellulose - 80 mg, magnesium stearate - 4.8 mg, - 15 mg.

Shell composition: macrogol 6000 - 9 mg, titanium dioxide - 11.25 mg, talc - 30 mg, hypromellose - 7.5 mg, methyl methacrylate and ethyl acrylate copolymer (1: 2) (dispersion 30%) - 2.25 mg.

20 pcs. - blisters (1) - packs of cardboard.

pharmachologic effect

Combined preparation of vitamins of group B.

(vitamin B 1) in the human body, as a result of phosphorylation processes, it turns into cocarboxylase, which is the coenzyme of many enzymatic reactions. Thiamine plays an important role in carbohydrate, protein and fat metabolism. Actively participates in the processes of nerve excitation in synapses.

(vitamin B 6) necessary for the normal functioning of the central and peripheral nervous system. In the phosphorylated form, it is a coenzyme in the metabolism of amino acids (including decarboxylation, transamination). It acts as a coenzyme for the most important enzymes that act in nerve tissues. Participates in the biosynthesis of neurotransmitters such as norepinephrine, epinephrine, histamine and GABA.

Cyanocobalamin (vitamin B 12) necessary for normal hematopoiesis and maturation of erythrocytes, and also participates in a number of biochemical reactions that ensure the vital activity of the body (in the transfer of methyl groups, in the synthesis of nucleic acids, protein, in the metabolism of amino acids, carbohydrates, lipids). It affects the processes in the nervous system (synthesis of RNA, DNA) and the lipid composition of cerebrosides and phospholipids. The coenzymatic forms of cyanocobalamin, methylcobalamin and adenosylcobalamin, are essential for cell replication and growth.

Pharmacokinetics

The components of the drug are water-soluble vitamins, which excludes the possibility of their accumulation in the body.

Suction and distribution

Thiamine and pyridoxine are absorbed in the upper intestine, the degree of absorption depends on the dose.

The absorption of cyanocobalamin is largely determined by the presence of intrinsic factor in the stomach and upper intestine, further delivery of cyanocobalamin to tissues is carried out by the transport protein transcobalamin II.

Metabolism

Thiamine, pyridoxine and cyanocobalamin are metabolized in the liver.

breeding

Thiamine and pyridoxine are excreted by the kidneys (about 8-10% - unchanged). With an overdose, the excretion of thiamine and pyridoxine through the intestines increases significantly.

Cyanocobalamin is excreted mainly with bile, the degree of excretion by the kidneys is variable - from 6 to 30%.

Indications

As part of the complex therapy of the following neurological diseases:

- polyneuropathy of various etiologies (including diabetic, alcoholic);

- intercostal neuralgia;

- trigeminal neuralgia;

- radicular syndrome caused by degenerative changes in the spine;

- cervical syndrome;

- shoulder-scapular syndrome;

- lumbar syndrome;

- lumbar ischialgia.

Contraindications

- children's age (the effectiveness and safety of the drug have not been studied);

- Hypersensitivity to the components of the drug.

Dosage

Side effects

In isolated cases: nausea, tachycardia, skin reactions in the form of itching and urticaria.

The drug is well tolerated.

Overdose

Symptoms: clinical symptoms of an overdose of the vitamins contained in the Neuromultivit preparation can only be expected after taking exceptionally high doses for a very long time.

Vitamin B 1 - symptoms of overdose after ingestion were not observed.

Vitamin B 6 - after taking more than 2 g / day, neuropathies with ataxia and sensory disturbances, convulsions with EEG changes and, in some cases, hypochromic anemia and seborrheic dermatitis are described.

Vitamin B 12 - after parenteral administration (in rare cases and after ingestion), eczematous changes in the skin and acne were observed.

Treatment: conducting symptomatic therapy.

drug interaction

With the simultaneous use of the drug Neuromultivit and levodopa, there is a decrease in the antiparkinsonian effectiveness of levodopa.

Active substances: One film-coated tablet contains:
Thiamine hydrochloride(vitamin B 1) - 100 mg,
Pyridoxine hydrochloride(vitamin B 6) - 200 mg,
cyanocobalamin(vitamin B 12) - 0.2 mg.
Excipients: pregelatinized starch, sodium citrate, citric acid monohydrate, anhydrous colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, povidone, macrogol 6000, titanium dioxide (E171), talc, hypromellose, dispersion polyacrylate 30%.

Pharmacotherapeutic group

Vitamins. Vitamin B 1 in combination with vitamin B 6 and/or B 12.
ATX code: A11DB

Pharmacological properties

Vitamin B 1 (thiamine hydrochloride) is involved in carbohydrate metabolism and affects the functional state of the nervous system.
Vitamin B 6 (pyridoxine hydrochloride) induces the metabolism of amino acids in nerve tissues and affects the biosynthesis of many well-known mediators such as dopamine, adrenaline and norepinephrine.
Vitamin B 12 (cyanocobalamin) affects, in particular, the metabolism of fatty acids in nerve tissues and is essential for cell growth and replication.

Indications for use

Neurological disorders caused by insufficiency of vitamins B 1 , B 6 and B 12, which cannot be eliminated by nutritional correction.

Contraindications

Hypersensitivity to any of the components that make up the drug. Due to the high content of active substances, the drug should not be taken by persons under 18 years of age.

Influence on the ability to drive vehicles or mechanisms

Neuromultivit does not affect the ability to drive vehicles or use machines.

Use during pregnancy and lactation

Due to insufficient experience, it is not recommended to use Neuromultivit during pregnancy and lactation.
Pregnancy
The recommended daily intake of vitamin B 1 during pregnancy and lactation is 1.7-1.8 mg, vitamin B 6 2.3-2.5 mg, vitamin B 12 3.5 mcg.
These doses can be exceeded during pregnancy only if the patient has a proven deficiency of vitamins B 1 , B 6 , B 12, since the safety of using doses above the daily recommended dose has not yet been proven.
There are insufficient animal studies on the effects on pregnancy, embryofetal and pre- and postnatal development of the offspring. The potential risk to humans is unknown.
Lactation
Vitamins B 1 , B 6 and B 12 pass into breast milk. High concentrations (600 mg per day) of vitamin B6 can suppress milk production. Data on the degree of transition into milk in animals are not available.

Interaction with other medicinal products and other forms of interaction

Vitamin B 6 may reduce the effectiveness of levodopa when used simultaneously. Thiamine is inactivated by 5-fluorouracil as a result of competitive inhibition of thiamine phosphorylation by the latter.
With long-term treatment with furosemide, an increase in renal excretion of thiamine is possible. Isoniazid, cycloserine, D-penicillamine can reduce the effectiveness of vitamin B 6 (pyridoxine).
Antacids, alcohol and tea reduce the absorption of thiamine.
Co-administration of pyridoxine antagonists (eg, isoniazid, hydralazine, D-penicillamine or cycloserine) may reduce the effectiveness of vitamin B 6 .
Sulfite-containing drinks (eg wine) contribute to the destruction of thiamine.

Special instructions and precautions for use

Tell your doctor immediately if you experience any side effects or if you are pregnant.
Treatment with large doses of the drug for longer than 4 weeks is not recommended.
When used in the elderly and in persons with impaired liver and / or kidney function, dose adjustment is usually not required.

Dosage and administration

The usual dose is one tablet once a day. However, after prior consultation with a doctor, the dose may be increased to 1 tablet 3 times a day.
Tablets should be swallowed without chewing after meals with a small amount of liquid.
The course of treatment should not exceed 4 weeks, after which the attending physician must decide on further therapy.
If you miss a tablet, take the next one at the usual time, do not double the dose to make up for the missed tablet.

Overdose

Vitamin B 1
There are no known cases of overdose.
Thiamine has a wide therapeutic range. Very high intravenous doses (more than 10 g) have a ganglioblocking effect and curare-like suppression of neuronal impulse transmission.
Vitamin B 6
Taking more than 2 g (equivalent to 10 Neuromultivit tablets) daily may cause nervous system dysfunctions such as movement disorders, sensory disturbances (tingling, numbness), convulsions and EEG changes. In rare cases, anemia and rash.
The toxic potential of vitamin B 6 is considered very low. However, long-term use (more than 6-12 months) of daily doses of vitamin B 6 50 mg causes the development of peripheral sensory neuropathy, these symptoms gradually decrease after the cessation of vitamin intake.
With continuous intake of vitamin B 6 for more than 2 months, in doses above 1 g per day, neurotoxic side effects may occur.
Vitamin B 12
After parenteral administration of high doses (in rare cases and after oral administration), allergic reactions, eczema and acne are observed.
Overdose treatment:
Treatment should be supportive and symptomatic.

Side effect

Like all medicines, Neuromultivit can cause side effects, although not everyone gets them.
The following adverse reactions have been registered:
Rare (less than one in 1000 patients): headache, dizziness, nausea.
- very rarely (less than one in 10,000 patients): hypersensitivity reactions, appearing mainly on the skin after the use of vitamin B 1 or B 12, itching, urticaria.
- with an unknown frequency (cannot be estimated from the available data): peripheral sensory polyneuropathy with prolonged use of more than 6 months, tachycardia, profuse sweating, chronic excessive intake of high doses of vitamin B 6 can cause sensitivity disorders, photosensitivity when using high daily doses of the drug .
Reporting adverse reactions
If you experience any adverse reactions, it is recommended that you consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the adverse drug reactions (actions) information database, including reports of drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug.