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Regulon is a contraceptive pill, a contraceptive with components that inhibit the action of hormones necessary for conceiving a child. In addition to the preventive effect, the drug is used for therapeutic purposes.

It is also prescribed to women who have hormonal disorders. It is suitable for the treatment of gynecological related diseases. According to reviews, Regulon, the instructions for use of which are discussed in detail in this article, eliminates such problems in 70% of cases.

The effect of OK on a woman's body

The drug Regulon belongs to the group of OK - oral contraceptives. There are 2 types of drugs: parenteral and tablet, performing the same goal - suppressing the production of female sex hormones. This cannot but affect health.

When taking OK, the natural work of the endocrine organs changes, in particular, the production of one's own progesterone and estrogen decreases. It should be borne in mind that after the abolition of oral contraceptives, it will take 3 months to establish this process.

Regulon normalizes the hormonal background of a woman due to the analogues of estrogen and progesterone contained in it. Regular intake of the drug prevents the development of a number of gynecological diseases.

The weight

Subject to the rules of admission, Regulon, like other OKs, will not be able to lead to weight gain. If this occurs, then the pills were chosen incorrectly.

The main goal of taking OK is to improve the health of a woman due to the stabilization of the hormonal background. Weight gain does not have a positive effect on health only if the patient is not emaciated or underweight.

Regulon: composition and form of release

The drug Regulon is released from pharmacies only by prescription of a gynecologist. The manufacturer of the Hungarian medicine is the pharmaceutical company GEDEON RICHTER Plc. OK is available in tablet form, the tablets are biconvex and round in shape. On both sides there are characteristic markings: P8, RG.

Regulon tablets have a film coating, have a color close to white. In the pharmacy, you can purchase 2 types of Regulon packages - with one and three blisters, each of which contains 21 tablets.

Mechanism of action

Synthesized hormonal components are the main substances that make up oral contraceptives. Progesterone and estrogen do not allow the egg to leave the ovary due to the prevention of its maturation. Thus, ovulation does not occur, which makes pregnancy impossible.

Also, the intake of such funds reduces the ability of the fallopian tubes to contract and increases the viscosity of the secret secreted by the uterine cervix. So, it is more difficult for spermatozoa to penetrate the uterine cavity.

Efficiency

Each patient noted positive or negative changes from taking Regulon. The effectiveness of the drug is confirmed by reviews, but this does not exclude the fact that side effects do occur.

Advantages of Regulon:

• improvement of the condition of hair, nails;
• elimination of acne;
• acceptable price;
• efficiency;
• breast enlarges;
• the pain disappears during menstruation.

Disadvantages of Regulon:

• high incidence of side effects (you can get fat);
• the need for individual selection (not everyone is suitable for Regulon);
• strong withdrawal syndrome.

Indications

The most common drug with an estrogen-progestogenic effect is taken to prevent pregnancy. However, in gynecological practice, Regulon is also used to correct hormonal balance, to get rid of menstruation.

Regulon is used to treat diseases such as:

• cystic formations in the chest and ovaries;
• uterine myoma;
• germination of tissue similar to the lining of the uterus into the uterus (adenomyosis);
• pain during menstruation (dysmenorrhea);
• growth of cells of the inner layer of the uterus beyond this area and their appearance in atypical places (endometriosis).

Reception scheme

The instructions for use of OK indicate how to take the drug. As a rule, doctors adhere to this scheme. A woman needs to remember that the main thing when using Regulon tablets is stability and responsibility. Before taking it, you should study the list of consequences and contraindications.

Start

You should start taking it on the first day of your period. You should choose the right time and stick to it throughout the course.

It is worth consuming 1 tablet per day (on the blister, all the days of admission are conveniently painted). After the 21st day, you need to take a break. It is not excluded the appearance of menstruation at this time. After 7 days, Regulon is taken again, regardless of whether menstruation has passed.

Missing a pill

If you miss more than 12 hours, you need to take 2 tablets the next day. Further - according to the scheme set out in the instructions. With a constant excess of the dose, an overdose is possible. However, until the end of the cycle, it is worth using additional methods of contraception.

Cancel

After stopping taking the pills, a withdrawal syndrome may occur - this is when the manifestation of side effects begins due to the fact that the body has stopped receiving previously administered substances. On the part of the reproductive system, the withdrawal of the drug is expressed in amenorrhea (absence of menstruation for more than six months), pain in the ovaries may appear, which is associated with the suppression of their function for a long time.

To properly complete the intake, it is worth drinking all the tablets in the package after the end of the menstrual cycle. Do not stop taking OK in the middle of a cycle. The woman's body is ready for conception 3 months after the drug is discontinued.

If the patient has been taking the drug for 5-15 years, then to complete the medication, you should act only under the guidance of a gynecologist. This situation requires a gradual decrease in the dose of hormones.

During the use of OK, a deficiency of vitamin B9 was formed. After the abolition of Regulon, it will not be superfluous to take folic acid.

Side effects

Most patients note an increase in the mammary glands, weight gain, increased emotionality and nausea. To reduce the risk of side effects, you should consult a highly qualified doctor.

In the instructions for the use of Regulon, the following side effects are noted (among the most common):

• bloody issues;
• epigastric pain;
• vomit;
• rash;
• depressive disorders;
• weight gain;
• fluid retention in the body;
• allergies;
• corneal hypersensitivity.

It is advisable to cancel the drug when the above consequences appear only after consulting a doctor and his decision, based on the ratio of risk and benefit to the body.

It may be necessary to stop taking the drug if such consequences appear (the likelihood of their occurrence is reduced if the drug was selected by a doctor):

• stool disorders;
• thrombosis;
• increased fatigue;
• gallbladder disease;
• fungus in the vagina;
• skin manifestations.

It is necessary to immediately stop using the drug if the following side effects of Regulon appear:

• unbearable pain;
• hemolytic-uremic syndrome;
• blurred vision;
• porphyria;
• incessant bleeding;
• a sharp increase in blood pressure;
• generalized itching;
• hearing loss (otosclerosis);
• epileptic seizures;
• progression of jaundice;
• symptoms of hepatitis without jaundice.

Contraindications

It is forbidden to use the drug in the presence of hypersensitivity to the components of Regulon. During lactation and when pregnancy occurs (or if it is suspected), you should also not take pills.

Contraindications to Regulon:

• migraine;
• angina;
• thrombosis;
• diabetes;
• pancreatitis;
• severe liver disease;
• jaundice;
• cholelithiasis;
• Gilbert's syndrome;
• vaginal bleeding.

Heavy smokers over 35 years of age (with an experience of more than 15 years or those who smoke 15 cigarettes a day) are prohibited from using the drug, as indicated in the instructions.

special instructions

The annotation to the drug Regulon describes special instructions for use. You should study them carefully.

The drug is prohibited in liver failure, and can be used with caution in liver diseases. If there are impaired renal function, then taking birth control pills is allowed only after an assessment of the benefits and risks.

Reception after childbirth and abortion

Often, a doctor after hormonal stress (which includes childbirth and a failed pregnancy) prescribes Regulon tablets. They should be taken in the same way as for other indications. OK helps to establish a menstrual cycle disturbed by medical abortion (curettage) or miscarriage, childbirth.

Pregnancy period

The course of treatment with the drug during pregnancy is prohibited, as with breastfeeding. If there is an urgent need to use the drug, lactation must be stopped.

The drug can be taken after breastfeeding, pregnancy. It is allowed to do this only after consulting a doctor.

menopause period

With menopause, Regulon is prescribed as a contraceptive (after all, the likelihood of conception is still preserved) to increase estrogen levels. The drug helps a woman cope with hormonal changes during this period, relieve menopausal syndrome.

drug interaction

The contraceptive increases the need for insulin, as well as for taking antidiabetic drugs. When taking any medication, you should study the compatibility with Regulon.

Efficacy may be reduced due to the use of the following substances (inducing liver enzymes):

• topiramate;
• barbiturates;
• griseofulvin;
• hydantoin;
• preparations of St. John's wort, etc.

Alcohol and smoking

The instructions for the use of Regulon do not say about the use of alcoholic beverages. It should be noted that OK affect the liver, as well as alcohol. A double load on the body is highly undesirable, so you should stop drinking alcohol.

Smoking is prohibited when taking OK, which is due to an increased risk of thrombosis.

Possible reasons for cancellation

When side symptoms or discomfort appear, it is not always worth canceling oral contraceptives. In some cases, the appearance of the consequences of taking does not indicate violations in the body. To make sure that drug withdrawal is required, you should consult with a gynecologist.

Discontinuation of the drug is necessary if:

• side effects are too strong and do not allow you to lead a normal life;
• there was a desire to give birth to a child;
• barrier contraception is needed;
• The patient does not lead a regular sexual life.

The reception should be canceled if the woman becomes pregnant. This has also happened in medical practice.

Pain

A severe migraine-like headache may be a reason to stop. If at the same time there is a sharp drop in vision, an ambulance should be called - this is one of the symptoms of a heart attack or thrombosis.

Pain in the lower abdomen when taking Regulon is a reason to go to the doctor.

Blood discharge

If the medication was prescribed after an ectopic pregnancy, in order to normalize the cycle, to eliminate a functional ovarian cyst, then bloody or brown discharge may be present in the first 30 days from the start of the intake. This is a normal phenomenon that occurs when you get used to the drug. In the following months, spotting should disappear.

Allocations should not continue in a row for more than 3 days. Blood may be present on linen even after discontinuation of the drug for 3-4 days. In all other cases, it is necessary to consult a specialist to replace the drug.

Pregnancy

Regulon is characterized by long-term use (it can be taken for more than 8 years). If a woman has decided to become pregnant, then oral contraceptives should be stopped 3 months before conception.

According to medical data, most often after the abolition of Regulon, pregnancy occurs within six months.

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 371

Description of the drug

In the 90s of the last century, scientists from the Gedeon Richter company were looking for ways to create their own method for obtaining the desogestrel molecule. As a result, a new generation of contraceptives was born - combined oral contraceptives, among which was Regulon. Over the years of use, there have been a lot of reviews about Regulon, and they were the most controversial. Someone is satisfied with it and recommends it for use, someone strongly disagrees and warns against taking it. But let's not forget that taking hormonal drugs is a purely individual matter, it should be selected by a doctor and it must be taken according to the instructions for using Regulon. Regulon is a low-dose contraceptive containing a combination of ethinyl estradiol and desogestrel. The last component is a modern progestogen that acts on the endometrium and has an antigonadotropic effect (inhibition of the production of gonadotrophic hormones by the pituitary gland). As a result, it is a reliable contraceptive, and in addition it can be used for hyperplastic processes of the endometrium. What causes its use not only in young women of reproductive age, but also in women in the premenopausal period. Especially advises this drug for use in women with rashes on the face.

Release form, composition and packaging

The presented drug is an oral monophasic contraceptive. The composition contains two main components: ● ethinylestradiol 30 mcg in 1 tablet; ● desogestrel 150 mcg in 1 tablet. As additionally used substances, the following are used: ● α-tocopherol - vitamin E, included in the medicine as an antioxidant; ● magnesium stearate - used as a separating agent in the creation of tablets by pressing; ● anhydrous colloidal silicon dioxide - aerosil. Helps to facilitate the process of coating the tablet, increases the strength of the shell, improves its appearance. It also accelerates the dissolution time of active substances; ● stearic acid - an emulsifier used to give the desired shape to the tablet, as well as to facilitate the mixing of components that are poorly connected to each other; makes the mixture homogeneous; ● Povidone K30 - thickener; ● potato starch - filler; ● lactose monohydrate - used to give the composition the form of a tablet. Produced in the form of biconvex white tablets, film-coated, which consists of the following components: ● propylene glycol; ● macrogol 6000; ● hypromellose.

Dosage

The dosage of Regulon is one, but there may be a different number of tablets. The packaging is represented by a pack of cardboard with blister blisters of 21 tablets each - for a one-month intake or there will be three blisters of 21 tablets each - a total of 63 tablets, which corresponds to a 3-month intake. On the surface of the blister, the ordinal numbering of the tablets is applied for ease of remembering the intake. Produced by the well-known Hungarian pharmaceutical company Gedeon Richter.

pharmachologic effect

A. Contraception. Regulon is a drug consisting of two hormones: 1. Ethinylestradiol is a synthetically created analogue of the hormone estradiol. The main and most active female sex hormone. Structurally, it is a steroid hormone. He is responsible for: ● formation and development of the female reproductive system; ● formation of secondary sexual characteristics; ● regulation of the menstrual cycle; ● egg growth; ● preservation of skin youth; ● used in endocrinology and oncology. 2. Desogestrel is a synthetically created progestogen. Its actions are as follows: ● suppression of ovulation - (release of a mature egg from the ovary); ● thickens the mucus of the cervical canal (canal of the cervix); ● lowers the level of estradiol; ● small androgenic activity; ● anabolic activity. The combination of these two hormones gives a high level of protective effect of Regulon tablets, which is achieved due to the fact that ovulation is suppressed, spermatozoa slow down through the cervical canal, and it is impossible for a fertilized egg to attach. B. Beneficial effect on lipid metabolism: ● increases the level of HDL - high density lipoproteins. They have the ability to cleanse blood vessels from accumulated fat deposits; ● has no effect on LDL - low density lipoproteins. C. reducing the emotional symptoms of premenstrual syndrome and reducing the amount of blood loss during menstruation. D. Beneficial effect on the skin, reduce acne.

Indications

Oral contraception.

Contraindications

Absolute contraindications: ● individual intolerance to the active or ancillary components of this medication; ● pregnancy or doubts about its presence; ● high blood pressure figures; ● the fact of violation of fat metabolism; ● previously recorded diseases of myocardial infarction; ● risk of formation of thromboembolism of veins or arteries; ● a history of genetic venous thromboembolism; ● diabetic angiopathy (pathological vascular damage caused by high sugar levels); ● depressing ailments of the liver; ● hepatitis (an inflammatory disease of the liver, most often caused by a virus), until complete recovery and improvement in all basic indicators; ● cholelithiasis; ● uterine fibroids; ● endometrial hyperplasia - a pathological process of tissue growth of the inner layer of the uterine cavity; ● bleeding from the external genital organs for unknown reasons; ● systemic lupus erythematosus (a chronic autoimmune disease caused by disruption of the immune mechanisms with the creation of antibodies that damage their own cells and tissues); ● history, previous genital herpes, the presence of itching and atherosclerosis; ● taking steroids.

Side effects

Side effects of Regulon, the manifestation of which entails the inevitable withdrawal of the drug: ● tests have found that oral hormonal contraceptives increase the likelihood of thromboembolism of arteries and veins, and contribute to the occurrence of complications in the form of acute cerebrovascular accident, pulmonary thromboembolism; ● in rare cases, vascular thromboembolism of the liver, kidneys and retina is possible; ● arterial hypertension (persistent increase in blood pressure); ● accelerates the growth of sex hormone-dependent tumors (uterine fibroids); ● possible development of congestive jaundice or the formation of stones in the bile ducts; ● exacerbation of systemic lupus erythematosus; ● Sydenham's chorea (involuntary, chaotic muscle contractions that stop during sleep) - goes away after stopping the drug. Side effects of Regulon of lesser severity (the issue of cancellation is decided individually): Reproductive system: ● bleeding that occurs between cycles; ● lack of menstruation; ● pain in the mammary glands. On the part of digestion: ● nausea; ● vomiting; ● bile stasis; ● formation of stones in the bile ducts. Skin: ● rashes, ● chloasma - foci of darker pigmentation of different sizes and with clear boundaries, located mostly on the face. From the side of the central nervous system: ● pain in the head; ● migraine; ● mood swings; ● depressed state. Organs of vision: ● possible increased susceptibility of the cornea in contact lens wearers. Metabolism: ● appearance of edema; ● decrease or increase in body weight.

Overdose

The use of significant doses of contraceptives may manifest appropriate symptoms: ● muscle cramps; ● headaches; ● nausea, vomiting. When taking a large number of tablets, gastric lavage is indicated in the first 3 hours. There is no specific antidote treatment. Help is symptomatic.

drug interaction

When choosing a contraceptive, be sure to tell your doctor about all the medicines you are taking. This may be important because some drugs interact with each other and may increase or decrease drug effects. So the simultaneous intake of antiepileptic drugs, antibiotics, tranquilizers (anti-anxiety drugs), laxatives, antispasmodics, St. John's wort and barbiturates, together with Regulon, can reduce the protective effect of the latter. Therefore, it is recommended to use an additional method of contraception, for example, a barrier method (using a condom, introducing spermacids into the vagina - substances that cause the death of spermatozoa, which are available in the form of creams, suppositories). If the patient's history is aggravated by the presence of diabetes mellitus, it may be necessary to revise the prescribed doses of the antidiabetic drug upwards.

special instructions

It is recommended to use Regulon with the onset of menstruation. Regulon during menstruation is taken on the day of their appearance. Then continue to use every day, once, without gaps, until the use of the last dragee. It is advisable to choose a convenient time, for example, in the evening, before going to bed, and it is during this interval that you drink the remaining pills. Before meals or after taking Regulon does not really matter. When the convoy is empty, a week-long break is made. During this period, bleeding occurs similar to the cycle of menstruation. A week later, everything repeats. Tablets from the next blister are used, even if bleeding continues. When following this mode, the protective property is preserved during the break. If the first few days the tablets were not taken (up to 5 days), then the first week of taking the drug should take care of additional protection measures. If Regulon is started according to the instructions, then additional measures are not required. When more than 5 days have passed since the onset of menstruation, it is better to postpone taking the drug until the next menstruation.

The use of the drug after the birth of a child

Women who are not breastfeeding should take the medicine 21 days after delivery. In this case, it is important to take care of the use of barrier methods of protection in the first week. It is also desirable to do when a decision is made to start taking pills later than three weeks later.

Reception after an abortion

The day when the intervention is made is the day of taking the first tablet of Regulon. In this case, the use of extra measures is not necessary.

Switching to the use of Regulon from another oral contraceptive

You drink the final pill and the next day, at the usual hours, start using the next Regulon tablets. You don't need to take a week off. There is no point in worrying about pregnancy. Switching to Regulon with "Mini-drank" (consisting of a low content of progestin). We accept the same as in the previous case. Additional contraceptive measures are not needed. If menstruation does not occur when using Mini-drank, then you can start using a new package at a convenient time, but you should not forget about additional measures. protection during the first week of admission.

Delaying the onset of menstruation

It happens that the onset of menstruation needs to be delayed, delayed. In order to delay this physiological process, you just need not to stop the consumption of Regulon, not to allow a weekly stop in taking the remedy. In this case, slight bleeding may occur, but they will not reduce the protective effect. It is possible to restore the usual mode of taking Regulon after the usual week of rest. Sometimes it turns out not to take the capsule on time, or you can simply not remember about it. If the time to skip a pill does not exceed 12 hours, take the pill that was not taken in a timely manner as soon as possible, and then take the next one at the usual time. If the skip time exceeds 12 hours, then it is considered that this contraception can no longer guarantee the result and it is necessary to use additional methods of contraception. When you miss one tablet during the first two weeks of your period, you need to drink a double dosage the next day and then take it regularly, remembering to use additional protection methods until the end of the cycle. When the medication was missed during the third week of the cycle, take the dragee that you forgot to take, continue taking the pills daily and do not take a weekly break. Here you need to remember that due to the forced break, at this time the likelihood of ovulation increases. Therefore, it is recommended to add a barrier method of contraception as insurance.

Signs of dyspepsia

If the onset of symptoms occurred after taking the pill, then most likely it did not have time to fully resolve. When loose stools and vomiting last less than 12 hours, it will be right to take an additional tablet. In the following days, Regulon's regimen should be observed as usual. In the case when diarrhea and nausea did not stop for more than 12 hours, do not forget that this indication is an additional precaution at the time of illness and for the next 7 days. A woman who smokes should definitely tell the prescribing doctor about this. Smoking enhances the ability of estrogens to form blood clots. Therefore, nicotine addiction in women, especially those over 35 years old, can be considered as an absolute ban on the use of any contraceptive drug. Stop taking the tablets immediately and seek medical attention if you experience any of the following symptoms: ● chest pain radiating to your left arm; ● unbearable pain in the legs; ● feeling of weakness; ● lack of air; ● feeling of numbness of any part of the body; ● occasional coughing; ● the appearance of pink sputum when coughing; ● dizziness; ● fainting; ● vision problems; ● deterioration of articulation; ● hearing problems; ● the strongest attack of migraine pains; ● yellowness of the skin; ● increase in blood pressure figures; ● occurrence of dense areas in the mammary glands; ● spontaneously arising pain in the lower abdomen or stomach area; ● bleeding from the genital tract; ● lack of menstruation for 2 months; ● feel the signs of pregnancy. It also makes sense to warn your attending gynecologist about the upcoming surgery or about the expected prolonged bed rest. In addition, before you start taking birth control pills, you must: ● undergo medical examinations by a therapist and gynecologist; ● determine the level of your blood pressure; ● make an anamnesis of their diseases and pathologies that close relatives had and have; ● submit basic tests for research and repeat them from time to time. If it happens that contraceptives need to be canceled, it is recommended to use all the remaining pills in the package. Abandoned in half, the reception will not have the best effect on the state of the hormonal background. And if you abruptly stop using Regulon in the first half of the menstrual cycle, the chances of getting pregnant in the near future increase many times over. During the period of drug withdrawal, it is better to stick to a diet, avoiding excessive consumption of sweet, fried, salty and fatty foods, since during this period the weight is unstable. The restoration of the usual natural cycle of menstruation after refusing to take a contraceptive occurs over the next few months. At first, incoming menstruation may be irregular and scanty. Don't worry. This is normal up to the first 12 weeks. Then, by the third month, everything is back to normal. But, the symptoms of premenstrual syndrome also return: ● irritability; ● swelling of the mammary glands; ● unmotivated mood swings; ● spasms in the head. If you abruptly exclude the use of contraceptive drugs that were used for therapeutic purposes (restoration of the menstrual cycle, endometriosis therapy), then a withdrawal syndrome with various symptoms may occur: ● uterine bleeding; ● decrease in working capacity; ● the appearance of a large number of inflammations on the face; ● decreased libido (sexual desire); ● spotting between periods; ● excessive hair growth.

Pregnancy and lactation

Numerous studies and experiments have shown that among children born to women who previously took hormonal contraceptives, there is no increase in the number of fetal formation disorders. Also, no pathological effect on the fetus of these drugs was found in the case when a woman took a contraceptive at the beginning of pregnancy. However, at the first suspicion of pregnancy, you should immediately stop taking the drug. Oral contraceptives reduce the amount of milk secreted, change its composition and is excreted with it in a small amount. Therefore, Regulon during pregnancy and breastfeeding is not recommended.

With impaired renal function

Regulon is prescribed after studying all the possible risks, comparing them with the likely benefits. If during the period of admission there are signs of deterioration in the functioning of the kidneys, the drug is stopped.

With violations of the liver

Tablets are not prescribed in the presence of liver disease in history: ● jaundice caused by stagnation of bile; ● hepatitis; ● the presence of jaundice at the hour of pregnancy; ● Dubin-Johnson syndrome (jaundice due to impaired delivery of bilirubin to the bile); ● Rotor's syndrome (chronic familial jaundice with normal liver histology); ● tumor processes; ● porphyria (congenital disease, accompanied by a violation of the structure and metabolism of hemoglobin); ● cholelithiasis. Taking contraceptives for liver diseases, it is necessary to undergo a periodic examination (every 2-3 months). If there are violations in the functioning of the liver, the drug should be discontinued.

Use in the elderly

Indications for the use of Regulon after 40 years of age take place and are successfully used to resolve the following issues: ● direct protection from pregnancy; ● normalization of hormonal levels; help reduce the manifestations of menopause (sagging, aging of the skin, dryness in the vagina, mood swings); ● treatment of gynecological diseases. So, the treatment of endometriosis with Regulon allows to achieve good results. Endometriosis is a fairly common ailment when the cells of the inner layer of the uterus, the endometrium, begin to grow. This leads to inflammation of the surrounding tissues and the appearance of symptoms such as: ● pain; ● increase in the size of the uterus; ● infertility. Other symptoms appear depending on the location. The positive aspects also include the fact that the drug does not affect body weight, normalizes the menstrual cycle, helps to get rid of pain. After six months of constant use, women notice an improvement in their well-being. But, with age, contraindications appear more and more. So, women older than 40-45 years are not recommended to take contraceptives in the following cases: ● oncological diseases; ● bronchial asthma; ● varicose veins; ● increased blood clotting; ● multiple sclerosis; ● phlebitis and thrombophlebitis; ● hypertension.

Conditions for dispensing from a pharmacy

You can buy Regulon at a pharmacy. Receipt leave. The price of Regulon depends on the number of pills in the package. A box for one month of admission costs an average of 365-370 rubles. Analogues of Regulon can also be found in pharmacies. These include: ● Novinet - contains 20 mcg of ethinylestradiol and 150 mcg of desogestrel in 1 tablet; ● Marvelon - the content of active substances in 1 tablet: 30 mcg of ethinylestradiol and 150 mcg of desogestrel; ● Mercilon - 1 tablet contains 20 micrograms of ethinylestradiol and 150 micrograms of desogestrel; ● Munali - in 1 tablet 0.02 mg of ethinyl estradiol and 0.15 mg of desogestrel. The composition of these tablets does not differ much in the doses of active substances, however, they are completely similar and identical in terms of the method of application.

Terms and conditions of storage

The storage temperature of the medicine is room temperature, from 15 to 30 degrees above zero. Keep away from children. Do not use after the expiration date, which is 3 years.

Regulon from the Hungarian pharmaceutical company GEDEON RICHTER is a monophasic tableted contraceptive. When the first contraceptives were synthesized in the fifties of the last century, hardly anyone could have imagined that their therapeutic effect on the female body would be valued almost more than the contraceptive effect. Long-term clinical studies have shown that patients who took combined oral contraceptives were much less likely to encounter not only gynecological, but also general somatic problems. In the course of improving the quantitative and qualitative composition of these drugs, an effective regimen was found, called prolonged, when the drug is taken continuously, without the traditional weekly interval. At the same time, it is possible to achieve not only the prevention of unplanned pregnancy, but also reduce the risk of developing many diseases. One of the drugs suitable for use in such a regimen is Regulon, a combination of ethinyl estradiol and desogestrel (third-generation progestogen). Even a relatively small amount of desogestrel in excess is enough to suppress ovulation (60 micrograms of the substance per day suppress ovulation by 100%). Back in the late 90s of the last century, it was noted that etonogestrel, the active metabolite of desogestrel, has an extremely high affinity for progesterone receptors, has high progestogenic activity and exhibits a powerful antigonadotropic effect.

One tablet of Regulon includes 150 micrograms of desogestrel, i.e. 2.5 times more of it than is necessary to completely suppress ovulation. Another component of the contraceptive action of the drug is its ability to inhibit the formation of gonadotropins. In addition to this, due to the change in the rheological properties of the mucus, the progression of spermatozoa along the cervical canal slows down, and the change in the thickness and structure of the endometrium does not allow the fertilized egg to be implanted on its mucosa. The second component of the drug - ethinylestradiol - is an artificial analogue of the female sex hormone estradiol produced in the body. Regulon improves the lipid profile, which is manifested in an increase in the concentration of high density lipoproteins ("good" cholesterol) while the content of low density lipoproteins ("bad" cholesterol) remains unchanged. Taking the drug can significantly reduce blood loss during menstruation (with existing menorrhagia), improve skin condition, and prevent acne. Before using Regulon, it is necessary to undergo an in-depth medical examination (history taking, blood pressure measurement, laboratory tests, gynecological examination). Such medical monitoring should be carried out during the period of use of the drug every six months.

Pharmacology

Monophasic oral contraceptive. The main contraceptive action is to inhibit the synthesis of gonadotropins and suppress ovulation. In addition, by increasing the viscosity of cervical mucus, the movement of spermatozoa through the cervical canal slows down, and a change in the state of the endometrium prevents the implantation of a fertilized egg.

Ethinylestradiol is a synthetic analog of endogenous estradiol.

Desogestrel has a pronounced gestagenic and antiestrogenic effect, similar to endogenous progesterone, weak androgenic and anabolic activity.

Regulon has a beneficial effect on lipid metabolism: it increases the concentration of HDL in the blood plasma, without affecting the content of LDL.

When taking the drug, the loss of menstrual blood is significantly reduced (with initial menorrhagia), the menstrual cycle is normalized, and a beneficial effect on the skin is noted, especially in the presence of acne vulgaris.

Pharmacokinetics

Desogestrel

Suction

Desogestrel is rapidly and almost completely absorbed from the gastrointestinal tract and is immediately metabolized to 3-keto-desogestrel, which is the biologically active metabolite of desogestrel.

C max is reached after 1.5 h and is 2 ng / ml. Bioavailability - 62-81%.

Distribution

3-keto-desogestrel binds to plasma proteins, mainly albumin and sex hormone-binding globulin (SHBG). V d is 1.5 l / kg. C ss is established by the second half of the menstrual cycle. The level of 3-keto-desogestrel increases 2-3 times.

Metabolism

In addition to 3-keto-desogestrel (which is formed in the liver and in the intestinal wall), other metabolites are formed: 3α-OH-desogestrel, 3β-OH-desogestrel, 3α-OH-5α-H-desogestrel (metabolites of the first phase). These metabolites do not have pharmacological activity and are partially, by conjugation (the second phase of metabolism), converted into polar metabolites - sulfates and glucuronates. Clearance from blood plasma is about 2 ml / min / kg of body weight.

breeding

T 1/2 3-keto-desogestrel is 30 hours. Metabolites are excreted in the urine and feces (in a ratio of 4:6).

Ethinylestradiol

Suction

Ethinylestradiol is rapidly and completely absorbed from the gastrointestinal tract. C max is achieved 1-2 hours after taking the drug and is 80 pg / ml. The bioavailability of the drug due to presystemic conjugation and the effect of "first pass" through the liver is about 60%.

Distribution

Ethinylestradiol is completely bound to plasma proteins, mainly to albumins. Vd is 5 l/kg. C ss is established by 3-4 days of administration, while the level of ethinylestradiol in serum is 30-40% higher than after a single dose of the drug.

Metabolism

Presystemic conjugation of ethinylestradiol is significant. Bypassing the intestinal wall (first phase of metabolism), it undergoes conjugation in the liver (second phase of metabolism). Ethinylestradiol and its conjugates of the first phase of metabolism (sulfates and glucuronides) are excreted into the bile and enter the enterohepatic circulation. Clearance from blood plasma is about 5 ml / min / kg of body weight.

breeding

T1 / 2 ethinylestradiol averages about 24 hours. About 40% is excreted in the urine and about 60% in the feces.

Release form

Tablets, film-coated, white or almost white, round, biconvex, marked "P8" on one side and "RG" on the other.

Excipients: α-tocopherol, magnesium stearate, colloidal silicon dioxide, stearic acid, povidone, potato starch, lactose monohydrate.

The composition of the film shell: propylene glycol, macrogol 6000, hypromellose.

21 pcs. - blisters (1) - packs of cardboard.
21 pcs. - blisters (3) - packs of cardboard.

Dosage

The drug is prescribed inside.

Reception of tablets is begun from the 1st day of a menstrual cycle. Assign 1 tablet / day for 21 days, if possible at the same time of day. After taking the last pill from the package, a 7-day break is taken, during which menstrual-like bleeding occurs due to drug withdrawal. The next day after a 7-day break (4 weeks after taking the first tablet, on the same day of the week), the drug is resumed from the next package, also containing 21 tablets, even if the bleeding has not stopped. This scheme of taking pills is followed as long as there is a need for contraception. Subject to the rules of admission, the contraceptive effect persists for the duration of the 7-day break.

First dose of the drug

The first tablet should be taken from the first day of the menstrual cycle. In this case, you do not need to use additional methods of contraception. You can start taking pills from the 2-5th day of menstruation, but in this case, in the first cycle of using the drug, additional methods of contraception should be used in the first 7 days of taking the pills.

If more than 5 days have passed since the start of menstruation, you should postpone the start of taking the drug until the next menstruation.

Taking the drug after childbirth

Women who are not breastfeeding can start taking pills no earlier than 21 days after giving birth, after consulting with their doctor. In this case, there is no need to use other methods of contraception. If after childbirth there was already sexual contact, then taking the pills should be postponed until the first menstruation. If a decision is made to take the drug later than 21 days after birth, then in the first 7 days it is necessary to use additional methods of contraception.

Taking the drug after an abortion

After an abortion, in the absence of contraindications, pills should be started from the first day after the operation, and in this case there is no need to use additional methods of contraception.

Switching from another oral contraceptive

When switching from another oral preparation (21- or 28-day): the first tablet of Regulon is recommended to be taken the next day after the completion of the course of the 28-day package of the drug. After completing the 21-day course, you must take the usual 7-day break and then start taking Regulon. There is no need to use additional methods of contraception.

Switching to Regulon after using progestogen-only oral hormonal preparations ("mini-pill")

The first tablet of Regulon should be taken on the 1st day of the cycle. There is no need to use additional methods of contraception.

If menstruation does not occur when taking the "mini-pill", then after the exclusion of pregnancy, you can start taking Regulon on any day of the cycle, but in this case, additional methods of contraception must be used in the first 7 days (use of a cervical cap with spermicidal gel, a condom, or abstinence from sexual intercourse). The use of the calendar method in these cases is not recommended.

Postponement of the menstrual cycle

If there is a need to delay menstruation, it is necessary to continue taking the tablets from the new package, without a 7-day break, according to the usual scheme. With a delay in menstruation, breakthrough or spotting bleeding may occur, but this does not reduce the contraceptive effect of the drug. Regular intake of Regulon can be restored after the usual 7-day break.

Missed pills

If a woman forgot to take a pill in a timely manner, and no more than 12 hours have passed after the missed one, you need to take the forgotten pill, and then continue taking it at the usual time. If more than 12 hours have passed between taking the pills - this is considered a missed pill, the reliability of contraception in this cycle is not guaranteed and the use of additional methods of contraception is recommended.

If you skip one tablet in the first or second week of the cycle, you need to take 2 tablets. the next day and then continue regular intake using additional methods of contraception until the end of the cycle.

If you miss a pill in the third week of the cycle, you must take the forgotten pill, continue to take it regularly and do not take a 7-day break. It is important to remember that due to the minimum dose of estrogen, the risk of ovulation and / or bleeding increases when a pill is missed, and therefore the use of additional methods of contraception is recommended.

Vomiting/diarrhea

If vomiting or diarrhea occurs after taking the drug, then the absorption of the drug may be defective. If the symptoms have stopped within 12 hours, then you need to take another tablet in addition. After that, you should continue taking the tablets in the usual way. If vomiting or diarrhea continues for more than 12 hours, then additional methods of contraception should be used during vomiting or diarrhea and for the next 7 days.

Overdose

Symptoms: nausea, vomiting, in girls - bloody discharge from the vagina.

Treatment: in the first 2-3 hours after taking the drug in a high dose, gastric lavage is recommended. There is no specific antidote, treatment is symptomatic.

Interaction

Drugs that induce liver enzymes, such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, St. John's wort, reduce the effectiveness of oral contraceptives and increase the risk of breakthrough bleeding. The maximum level of induction is usually reached no earlier than 2-3 weeks, but may last up to 4 weeks after discontinuation of the drug.

Ampicillin and tetracycline reduce the effectiveness of Regulon (the mechanism of interaction has not been established). If co-administration is necessary, it is recommended to use an additional barrier method of contraception throughout the course of treatment and for 7 days (for rifampicin - within 28 days) after discontinuation of the drug.

Oral contraceptives may decrease carbohydrate tolerance, increase the need for insulin or oral antidiabetic agents.

Side effects

Side effects requiring discontinuation of the drug

From the side of the cardiovascular system: arterial hypertension; rarely - arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism); very rarely - arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins.

From the senses: hearing loss due to otosclerosis.

Others: hemolytic uremic syndrome, porphyria; rarely - exacerbation of reactive systemic lupus erythematosus; very rarely - Sydenham's chorea (passing after discontinuation of the drug).

Other side effects that are more common but less severe. The expediency of continuing the use of the drug is decided individually after consultation with a doctor, based on the benefit / risk ratio.

On the part of the reproductive system: acyclic bleeding / bloody discharge from the vagina, amenorrhea after discontinuation of the drug, changes in the state of vaginal mucus, the development of inflammatory processes in the vagina, candidiasis, tension, pain, enlargement of the mammary glands, galactorrhea.

From the digestive system: nausea, vomiting, Crohn's disease, ulcerative colitis, the occurrence or exacerbation of jaundice and / or itching associated with cholestasis, cholelithiasis.

Dermatological reactions: erythema nodosum, erythema exudative, rash, chloasma.

From the side of the central nervous system: headache, migraine, mood lability, depression.

On the part of the organ of vision: increased sensitivity of the cornea (when wearing contact lenses).

On the part of metabolism: fluid retention in the body, change (increase) in body weight, decreased tolerance to carbohydrates.

Other: allergic reactions.

Indications

Contraception.

Contraindications

• the presence of severe and / or multiple risk factors for venous or arterial thrombosis (including severe or moderate arterial hypertension with blood pressure ≥ 160/100 mm Hg);
• the presence or indication in the anamnesis of the precursors of thrombosis (including transient ischemic attack, angina pectoris);
• migraine with focal neurological symptoms, incl. in history;
• venous or arterial thrombosis / thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower leg, pulmonary embolism) at present or in history;
• the presence of venous thromboembolism in history;
• diabetes mellitus (with angiopathy);
• pancreatitis (including history), accompanied by severe hypertriglyceridemia;
• dyslipidemia;
• severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. in history (before the normalization of functional and laboratory parameters and within 3 months after their normalization);
• jaundice when taking GCS;
• cholelithiasis at present or in history;
• Gilbert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome;
• liver tumors (including history);
• severe itching, otosclerosis or its progression during a previous pregnancy or taking corticosteroids;
• hormone-dependent malignant neoplasms of the genital organs and mammary glands (including if they are suspected);
• vaginal bleeding of unknown etiology;
• smoking over the age of 35 (more than 15 cigarettes per day);
• pregnancy or suspicion of it;
• lactation period;
• hypersensitivity to the components of the drug.

The drug should be prescribed with caution in conditions that increase the risk of developing venous or arterial thrombosis / thromboembolism: age over 35 years, smoking, family history, obesity (body mass index more than 30 kg / m 2), dyslipoproteinemia, arterial hypertension, migraine, epilepsy, valvular heart disease, atrial fibrillation, prolonged immobilization, extensive surgery, surgery on the lower extremities, severe trauma, varicose veins and superficial thrombophlebitis, postpartum period, severe depression (including history), changes in biochemical parameters ( activated protein C resistance, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, antiphospholipid antibodies, including antibodies to cardiolipin, including lupus anticoagulant), diabetes mellitus not complicated by vascular disorders, SLE, Crohn's disease , ulcerative colitis, sickle cell anemia, hypertriglyceridemia (including . family history), acute and chronic liver disease.

Application features

Use during pregnancy and lactation

The use of the drug during pregnancy and lactation is contraindicated.

During lactation, it is necessary to resolve the issue of either discontinuing the drug or stopping breastfeeding.

Application for violations of liver function

Contraindicated in liver failure.

With caution, the drug should be prescribed for acute and chronic liver diseases.

Application for violations of kidney function

With caution and only after a thorough assessment of the benefits and risks of use, the drug should be prescribed for renal failure (including history).

special instructions

Before starting the use of the drug, it is necessary to conduct a general medical (detailed family and personal history, measurement of blood pressure, laboratory tests) and gynecological examination (including examination of the mammary glands, pelvic organs, cytological analysis of a cervical smear). A similar examination during the period of taking the drug is carried out regularly, every 6 months.

The drug is a reliable contraceptive: the Pearl index (an indicator of the number of pregnancies that occurred during the use of a contraceptive method in 100 women for 1 year), when used correctly, is about 0.05.

In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception.

The state of health of women must be carefully monitored. If any of the following conditions / diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:

• diseases of the hemostasis system;
• conditions/diseases predisposing to the development of cardiovascular, renal failure;
• epilepsy;
• migraine;
• the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;
• diabetes mellitus, not complicated by vascular disorders;
• severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B 6 can be used for correction);
• sickle cell anemia, tk. in some cases (for example, infections, hypoxia), estrogen-containing drugs in this pathology can provoke thromboembolism;
• the appearance of abnormalities in laboratory tests for assessing liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is a link between taking oral hormonal contraceptives and an increased risk of developing arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic disease has been proven, but it is significantly less than during pregnancy (60 cases per 100,000 pregnancies).

Some researchers suggest that the likelihood of developing venous thromboembolic disease is greater with the use of drugs containing desogestrel and gestodene (drugs of the third generation) than with drugs containing levonorgestrel (drugs of the second generation).

The frequency of spontaneous occurrence of new cases of venous thromboembolic disease in healthy non-pregnant women not taking oral contraceptives is about 5 cases per 100,000 women per year. When using second-generation drugs - 15 cases per 100 thousand women per year, and when using third-generation drugs - 25 cases per 100 thousand women per year.

When using oral contraceptives, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is very rarely observed.

The risk of developing arterial or venous thromboembolic diseases increases:

• with age;
• when smoking (heavy smoking and age over 35 are risk factors);
• if there is a family history of thromboembolic diseases (for example, in parents, a brother or sister). If a genetic predisposition is suspected, it is necessary to consult a specialist before using the drug;
• with obesity (body mass index more than 30 kg / m 2);
• with dyslipoproteinemia;
• with arterial hypertension;
• in diseases of the heart valves, complicated by hemodynamic disorders;
• with atrial fibrillation;
• with diabetes mellitus complicated by vascular lesions;
• with prolonged immobilization, after major surgery, after surgery on the lower extremities, after a severe injury.

In these cases, a temporary discontinuation of the drug is expected (no later than 4 weeks before surgery, and resumed no earlier than 2 weeks after remobilization).

Women after childbirth have an increased risk of venous thromboembolic disease.

It should be borne in mind that diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia, increase the risk of developing venous thromboembolic diseases.

It should be borne in mind that resistance to activated protein C, hyperhomocysteinemia, deficiency of proteins C and S, deficiency of antithrombin III, the presence of antiphospholipid antibodies increase the risk of developing arterial or venous thromboembolic diseases.

When assessing the benefit / risk ratio of taking the drug, it should be taken into account that targeted treatment of this condition reduces the risk of thromboembolism. The symptoms of thromboembolism are:

• sudden chest pain that radiates to the left arm;
• sudden shortness of breath;
• any unusually severe headache that lasts for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of one side of the body, movement disorders, severe unilateral pain in the calf muscle, sharp abdomen.

Tumor diseases

Some studies have reported an increase in the occurrence of cervical cancer in women who have been taking hormonal contraceptives for a long time, but the results of the studies are conflicting. Sexual behavior, human papillomavirus infection and other factors play a significant role in the development of cervical cancer.

A meta-analysis of 54 epidemiological studies showed that there is a relative increase in the risk of breast cancer among women taking oral hormonal contraceptives, but the higher detection of breast cancer could be associated with more regular medical examinations. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. Taking pills can be regarded as one of many risk factors. However, women should be advised of the potential risk of developing breast cancer based on a benefit-risk assessment (protection against ovarian and endometrial cancer).

There are few reports of the development of benign or malignant liver tumors in women who take hormonal contraceptives for a long time. This should be kept in mind in the differential diagnostic evaluation of abdominal pain, which may be associated with an increase in the size of the liver or intraperitoneal bleeding.

Chloasma can develop in women who have a history of this disease during pregnancy. Those women who are at risk of developing chloasma should avoid contact with the sun's rays or ultraviolet radiation while taking Regulon.

Efficiency

The effectiveness of the drug may decrease in the following cases: missed pills, vomiting and diarrhea, simultaneous use of other drugs that reduce the effectiveness of birth control pills.

If the patient is simultaneously taking another drug that can reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may decrease if, after several months of their use, irregular, spotting or breakthrough bleeding appears, in such cases it is advisable to continue taking the tablets until they are finished in the next package. If, at the end of the second cycle, menstrual bleeding does not begin or acyclic spotting does not stop, stop taking the tablets and resume it only after pregnancy has been excluded.

Changes in laboratory parameters

Under the influence of oral contraceptive pills - due to the estrogen component - the level of some laboratory parameters (functional parameters of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.

Additional Information

After suffering acute viral hepatitis, the drug should be taken after normalization of liver function (not earlier than after 6 months).

With diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease. Without stopping taking the drug, it is necessary to use additional non-hormonal methods of contraception.

Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35) and on the number of cigarettes smoked.

A woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Influence on the ability to drive vehicles and control mechanisms

The drug does not affect the ability to drive a car and work with mechanisms.

Increasingly, women are choosing oral medications as their choice. pills will not only protect against unwanted pregnancy, but also stabilize the hormonal background and the menstrual cycle. One of the most famous representatives of such hormonal agents is Regulon, a new generation monophasic drug with proven high efficiency.

Tool Description

Regulon tablets are round, white in color and marked on both sides - "RG" on one side and "P8" on the other side. The tablets are packed in a blister, on the surface of which the serial numbers of the tablets are affixed, and it is also possible to mark the day of the week when the drug is taken.

The contraceptive is based on two hormones: ethinylestradiol and desogestrel. Ethinylestradiol is a synthetic (that is, artificially produced) analogue of the hormone estradiol. Its molecular structure is absolutely identical to the structure of the natural prototype. Desogestrel is the chemical analogue of progesterone.

More about the main hormones

Ethinylestradiol is used to treat diseases of the endocrine system, oncology.

But the main area of ​​application remains gynecology.

Medicines with ethinyl estradiol are prescribed for the following problems:

With prolonged use of drugs with synthetic estrogen, thickening of the endometrium, mucous membranes of the vagina and cervix occurs. The concentration of cholesterol and its derivatives in the blood decreases.

Desogestrel affects the viscosity of cervical mucus, regulates hormonal levels to a level corresponding to the early follicular phase, and causes inhibition of ovulation. The scope of desogestrel is limited only to contraception.

The mechanism of action of the contraceptive

The combination of two hormones guarantees a high level of the contraceptive effect of Regulon. The Pearl Index - an indicator characterizing the level of reliability of the method of protection - for Regulon is in the range from 0.1 to 0.9. For comparison, the Pearl index ranges from 0.9-3 depending on the manufacturer.

These indicators are achieved due to the fact that:

In addition to the main task - protection against unwanted pregnancy - "Regulon" stimulates lipid metabolism, which allows some ladies to lose weight, reduces blood loss during menstruation and reduces the amount of acne on the skin. It was noted that when taking Regulon, the manifestations of PMS, both emotional and general somatic, can completely disappear.

Contraindications and side effects

Before you purchase, be sure to consult a gynecologist. This rule applies not only to Regulon, but also to any other drugs.

The use of Regulon is contraindicated in the following cases:

Some ladies observe side effects when taking Regulon, which force them to refuse or select another remedy.

Individual body reactions are almost impossible to predict, and often the result of taking the drug is strikingly different from the expected.

The most frequent - based on the observations of doctors and reviews - The side effects of Regulon are as follows:

Rules for taking birth control pills

In order not to get pregnant, it is important to take Regulon correctly, following the recommendations indicated in the instructions.

You need to start taking the drug on the first day of the cycle, that is, on the day the menstruation begins. In the event that a woman began to drink pills in the period from the second to the fifth day of the cycle, it is recommended to use condoms for a week as an additional protection. If the start of taking Regulon occurred later than the 5th day of the cycle, the effectiveness of the remedy is significantly reduced, and there is a risk of becoming pregnant.

One package of "Regulon" is designed for one menstrual cycle, that is, you need to take one tablet once a day. It is recommended to observe 24-hour time intervals and drink tablets at approximately the same time of day. In order not to forget about birth control, you can set a reminder on your smartphone.

If a girl missed taking the birth control pill at the usual time, then according to the instructions, you can drink the medicine for 12 hours, while the effectiveness of the contraceptive will not be reduced. If 12 hours have already passed, then it is important to follow the manufacturer's recommendations:

• in the first two weeks of the cycle, it is enough to take 2 birth control pills the next day after the pass and use barrier methods of contraception until the end of the package;
• at a later date, you need to continue taking the tablets according to the usual scheme, that is, 1 piece per day, but at the same time refuse to take a break and immediately start using the drug from the next after the end of one package.

After 21 regular pills, it's time for a seven-day break. During this period, menstruation should normally take place. On the eighth day, even spotting continues, you need to open a new package of pills and start taking the pills.

In some cases, girls do not take a break and immediately start taking pills from the next package. This helps to push the menstruation to a later date. Most often, women resort to this method in order to comfortably spend their holidays and not worry about the condition of the swimsuit. Even more often, athletes artificially regulate their cycle so as not to weaken the body during the competition.

Whatever the reasons, it is important to remember that the manufacturer, although it allows the possibility of taking several packages in a row, does not recommend using this method for a long time. No more than two packs of 21 tablets can be taken without interruption.

Special situations

Gynecologists can prescribe birth control pills for women after childbirth, for example, if it is undesirable to breastfeed the baby, and also after an abortion.

Regulon in the first case, you need to start drinking 21 days after the birth of the baby.

After an abortion, birth control pills begin to be used on the first day. Taking hormonal drugs after an abortion is necessary to restore the normal functioning of the ovaries and compensate for the synthesis of progesterone, which was reduced during pregnancy.

The transition to Regulon after the abolition of other hormonal drugs is as follows:

• if there are 28 tablets in a package of a contraceptive, Regulon is taken the next day after the 28th tablet is drunk;
• if there are 21 tablets in the package, then after the end of the intake, you need to take a break of 7 days and start taking Regulon on the eighth day.

To protect yourself, in the first seven days of taking Regulon, it is recommended to use additional non-hormonal methods of protection or refrain from intimacy in order to avoid undesirable consequences.

Reducing the effect

The effectiveness of Regulon may be affected by other medicines if taken at the same time. These are mainly antibiotics, hepatoprotectors, antidepressants and some types of antispasmodics.

The manufacturer does not guarantee 100% safety in case of vomiting, loose stools and missed doses.

Particular attention should be paid to the presence of irregular bleeding outside the 7-day break period. If a girl has noticed such a symptom in herself, she needs to continue taking the pills from the current cycle and check for the presence of menstruation during the break between packs. The absence of menstrual bleeding or the appearance of traces of spotting at an unusual time can be a sign of pregnancy.

Regulon- a combined contraceptive, which includes an estrogen component (ethinyl estradiol) and a progestogen (desogestrel). The mechanism of action is associated with inhibition of the production of gonadotropins (FSH and luteinizing hormones) by the pituitary gland, which makes it difficult to ovulate and increase the density of cervical mucus, which prevents the penetration of spermatozoa into the uterine cavity.

Indications for use

- contraception;
- treatment of menstrual disorders such as dysmenorrhea, PMS, dysfunctional uterine bleeding.

Mode of application

Should start taking the drug Regulon from the first day of the menstrual cycle, without the use of additional methods of contraception. If the first dose Regulon falls on days 2-5 of the menstrual cycle, contraception by other methods is recommended for at least a week. If more than 5 days have passed since the beginning of the cycle, taking Regulon should start with the next cycle.

The drug is taken 1 tablet 1 time per day, preferably at the same time, after taking 21 tablets, a break is required for a week, during which a menstrual-like reaction occurs. A week later, start taking a new package of the drug Regulon even if the bleeding hasn't stopped yet.
After childbirth, taking the drug is possible only when the woman is not breastfeeding. Start taking the drug from the 21st day of the postpartum period. If there has already been sexual intercourse since the birth, it is necessary to postpone taking the drug until menstruation. When taking the first Regulon tablets after 21 days of the postpartum period, additional contraception is required for 7 days.

When switching from another oral contraceptive, it is recommended to start taking the drug Regulon the next day after the end of taking all the pills from the package of the previous contraceptive.
If you need to delay the onset of the next menstruation, you should start taking the pills from the next package, without a week break.

Side effects

On the part of the gastrointestinal tract: nausea, vomiting, extremely rarely - impaired liver function.
On the part of the reproductive organs and the reproductive system: intermenstrual bleeding, amenorrhea, disturbances in the composition of the normal microflora of the vagina, changes in the vaginal secretion, decreased libido, discomfort in the mammary glands. Very rare growth of uterine fibroids.
On the part of the circulatory organs: increased blood pressure, very rarely thrombosis and thromboembolism of various localization.
From the side of the central nervous system: frequent mood swings, depression, headache, usually migraine-like in nature.
From the endocrine system: weight gain.
Others: rash, erythema nodosum, discomfort when wearing contact lenses, development of reactive SLE.

Contraindications

- intolerance to any of the components of the drug;
- pregnancy or lactation;
- severe liver disease, functional hyperbilirubinemia (Rotor and Dubin-Johnson syndrome), history of jaundice in pregnancy;
- family forms of hyperlipidemia;
- severe or moderate arterial hypertension;
- history of thrombosis or thromboembolism;
- migraine;
- SLE;
- herpes type 2;
- bleeding from the genital tract of unknown etiology;
- the presence of estrogen-dependent tumors or suspicion of them;
- epilepsy;
- severe forms of diabetes mellitus, as well as diabetes in pregnant women;
- the presence of violations of the coagulation system.

Pregnancy

The state of pregnancy is an absolute contraindication to prescribing the drug.

Interaction with other drugs

Do not use simultaneously with antibiotics (especially ampicillin, rifampicin, tetracycline), as it is possible to disrupt the cycle and reduce the contraceptive effect. If these antibiotics are necessary, additional methods of contraception may be required. It is also possible to reduce the effect of contraception and disrupt the cycle when taking barbiturates, some antispasmodics, antidepressants, laxatives.
When combined with anticoagulants, additional monitoring of prothrombin time and dose adjustment of the anticoagulant are required.
Do not combine with hepatotoxic agents due to an increased risk of complications.

Overdose

Overdose symptoms: severe headache, dyspepsia, cramps in the calf muscles. Therapy is only symptomatic, since there is no specific antidote.

Release form

Coated tablets, 21 or 63 tablets per pack.

Storage conditions

Store at a temperature not exceeding 30 degrees Celsius.

Compound

Ethinylestradiol - 0.03 mg.
Desogestre - 0.15 mg.

Excipients: magnesium stearate, alpha-tocopherol, anhydrous colloidal silicon, povidone, potato starch, lactose monohydrate, propylene glycol, macrogol, hypromellose, stearic acid.

Additionally

Purpose Regulon occurs after a thorough examination and history taking, in order to exclude the presence of diseases, the course of which may worsen while taking the drug.
If liver tests worsen (transaminase levels, bilirubin), the drug should be stopped immediately.
In the first months of taking the drug, intermenstrual bleeding may occur, but these symptoms do not require discontinuation of the drug. If they last more than three months, a more detailed examination is necessary.

The risk of thromboembolic complications increases with smoking, so women taking Regulon, it is recommended to completely abandon cigarettes.
With vomiting or diarrhea, the contraceptive effect of the drug may decrease, so it is better to use additional methods of contraception.
If pregnancy is planned, Regulon must be discontinued at least 3 months in advance.

If from the second month of taking the drug there is no menstrual-like reaction, pregnancy should be excluded.
When breastfeeding, Regulon is not prescribed, as the drug can lead to a decrease in lactation.
If a tablet is missed, take the tablet that was missed and continue taking the drug according to the scheme. If the missed tablet is taken within 36 hours of the previous one, no additional contraceptive measures are required.
The terratogenic effect of the drug has not been proven, therefore, pregnancy that occurred while taking Regulon does not require interruption.

Main settings

Name:	REGULON
ATX code:	G03AA09 -